Choroidal Melanoma Detection Device and software
is a malignant tumor derived from pigment cells initiated in the choroid. Fluorescein and ICG angiography can aid in determining the characteristics of the retinal and choroidal circulation around the tumor mass and can confirm the diagnosis.
Acute Zonal Occult Outer Retinopathy
is characterized by a rapid loss of one or more large zones of outer retinal function, and permanent visual field loss that is associated with delayed development of visible atrophic changes in the RPE. optomap color shows hypopigmentation consistent with an inflammatory or infectious process. optomap af shows hyperautofluorescent lesions that correspond to hypopigmentation on the optomap color that extend from the posterior pole to the periphery. optomap icg shows the location of the lesions and may help to rule out vasculitis or inflammatory diseases.
is a rare immune-mediated disease that may cause inflammation from circulating autoantibodies against the retina. It may be related to history of autoimmune disease in the patient or in a family member or the presence of neoplastic disease in the individual. In autoimmune retinopathy, arteries and veins can appear attenuated as seen on the optomap images. ICG angiography is used to rule out inflammatory/vasculitic disease
is an genetic eye disorder that involves the choroid, often resulting in areas of atrophy in the retinal pigment epithelium and the choriocapillaris.
Retinal Dystrophy is a term given to a range of genetic conditions with varying pathologic manifestations including, Leber Congenital Amaurosis and Rod-Cone Dystrophies such as, Retinitis Pigmentosa, Stargardt’s disease, Best’s disease, Usher Syndrome, Batten Disease and Bardet-Biedl. optomap color shows hypopigmented pathologic changes from the central pole to the peripheral retina. optomap af shows hyperautofluorescence around an area of hypoautofluorescence of the RPE from photoreceptor loss and dysfunction, which indicates disease progression. optomap fa shows window defect from RPE dysfunction or degeneration in those areas. optomap icg shows consistency with RPE disturbances as seen in the other imaging modalities and increase visualization of the choroid.
Vasculitis Screening Device and software
Vasculitis is inflammation of blood or lymph vessels. optomap color shows atrophy, vessel sheathing, ischemia and inflammation. Due to the atrophic changes that are present, optomap icg shows vasculitic changes within the choroidal tissues. Vessel hypercyanescence is present due to vessel staining and leakage
Multifocal Evanescent White Dot Syndrome Screening Device and SOFTWARE
MEWDS a condition in which white dots appear in the deep layers of the retina caused by inflammation. optomap color shows subtle RPE disturbances centered on the macula. optomap af shows increases in RPE hyperautofluorescence in the posterior pole to the periphery. optomap fa shows leakage in a circular pattern around the fovea spreading into the peripheral retina. optomap icg shows the absence of the MEWDS lesions in the choroid and may help to rule out other inflammatory diseases. If the lesions are not visible with the optomap icg, then this may suggest this is MEWDS.
Birdshot Chorioretinitis is an inflammatory disease of the choroid, characterized by small, yellowish choroidal spots and vitreous inflammation. optomap color shows areas of hypopigmentation extending to the far periphery. optomap af shows hyperautofluorescence areas corresponding to the inflammatory spots. The spots are not easily visible in optomap fa as the other imaging modalities due to the location of the spots in the choroid. optomap icg shows inflammatory spots which result in small choroidal hypocyanescent lesions.
Multifocal Choroiditis is an inflammatory condition that can manifest with vitritis and chorioretinal lesions extending from the posterior pole. Multimodal imaging shows hypopigmentation on the optomap color image. optomap af demonstrates retinal pigment epithelial (RPE) hyperautofluorescence. optomap fa shows pinpoint areas of leakage with vasculitis. optomap icg shows areas of hypocyanescence which are perfusive inflammatory changes in the central and peripheral choroid.
Uveitis is inflammation of any of the structures of the uvea: iris, ciliary body or choroid. Interweave fa/icg is useful when imaging uveitis. optomap fa shows localized and diffuse leakage throughout the retina. optomap icg shows the inflammatory lesions seen on optomap fa for confirmation of disease. Images may appear slightly blurred due to inflammatory cells in the vitreous, called vitreous haze, or due to vasculitis.
(VKH) optomap Lesions/inflammatory areas found in VKH correspond across multimodal imaging. fa shows areas of hyperfluorescence due to staining of inflammatory foci. FA Color ICG angiography is used to visualize inflammatory leakage and vasculitic changes such as, early choroidal vessel hypercyanescence and leakage, hypocyanescent dark lesions, a blurry vascular pattern and disc hypercyanescence. ICG angiography can pinpoint the inflammatory lesions that were seen in multimodal imaging to confirm the disease.
Central Serous Chorioretinopathy
CSCR, CSR) Multimodal imaging is helpful in visualizing CSCR. optomap color shows areas of hypopigmentation from chronic epithelial retinal detachments. optomap af shows fluid collections with hyperautofluorescence present. optomap fa shows pinpoint leakage and pooling. optomap icg shows choriocapillaris leakage points which may be a potential conversion to neovascularization.
Polypoidal Choroidal Vasculopathy
PVC is a choroidal vasculature disease, characterized by recurring subpigment epithelial bleeding and polyps seen in early phase ICG angiography. ICG angiography is often used for diagnosing PCV and helps determine and guide treatment. It is more common in Asian populations.
is usually evident as a disturbance of macular pigmentation and drusen which are deposits of yellowish material under the pigment epithelial layer in the central retinal zone. Geographic Atrophy (GA) associated with dry AMD, is any sharply delineated round or oval area of hypopigmentation, or apparent absence of the retinal pigment epithelium (RPE) at least 175 m in diameter, in which choroidal vessels are more visible than in the surrounding areas.
Age-Related Macular Degeneration
is a group of conditions that include deterioration of the macula, resulting in loss of sharp central vision. There are two types of AMD: wet and dry. Wet AMD is abnormal new blood vessel growth under the retina which leaks fluid and blood, further disturbing macular function. ICG angiography is more commonly used for wet AMD.
Choroidal Neovascular Membrane
is associated with wet AMD and there are three types: Classic, Retina Angiomatous Proliferation (RAP) and Occult. On ICG angiography, classic CNV may appear in the early phase with a well-defined area of hypercyanescence. RAP presents as a well-defined single vessel which is hypercyanescent in the early ICG phase unless blocked by pre-retinal hemorrhage causing hypocyanescence. Occult may appear as poorly defined and areas of neovascularization are blurry, bright hypercyanescent regions.